Source Name: 2024_Ly
Literature Information
| Literature Title | Insights on Structure–Passive Permeability Relationship in Pyrrole and Furan-Containing Macrocycles |
| Doi | 10.1021/acs.jmedchem.3c02162 |
| Research Group |
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| Data Number | 20 |
| Minimum Molecular Weight | 439.6 |
| Maximum Molecular Weight | 468.6 |
Assay Information 1
| Assay Type | PAMPA |
| Permeability Type | logPe |
| Membrane Measurement Direction (Exclude PAMPA) | - |
| Assay Detail | The assay was carried out with 10 μL membrane (2% lecithin in dodecane), using a 100 μM solution in a phosphate butter (pH = 6.4) and shaken for 17 h (37 °C, 150 rpm). All experiments were conducted in triplicates. The PAMPA assay was performed on 200 μL hydrophobic 0.45 μm PVDF 96-well filter plates (Millipore MAIPNTR10) and 300 μL receiver plates (Millipore MATRNPS50). |
Assay Information 2
| Assay Type | Caco2 |
| Permeability Type | logPapp |
| Membrane Measurement Direction (Exclude PAMPA) | N.D |
| Assay Detail | N.D |