Source Name: 2019_Ono

Literature Information

Literature Title Conformation and Permeability: Cyclic Hexapeptide Diastereomers
Doi 10.1021/acs.jcim.9b00217
Research Group
  1. Mitsubishi Tanabe Pharma Corporation
  2. Department of Chemistry and Biochemistry, University of California Santa Cruz
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Data Number 8
Minimum Molecular Weight 712.9
Maximum Molecular Weight 712.9

Assay Information 1

Assay Type PAMPA
Permeability Type logPapp
Membrane Measurement Direction (Exclude PAMPA) -
Assay Detail Briefly, a membrane was prepared on a 96-well filter support (donor) with a 1% (w/v) solution of lecithin (soybean) in n-dodecane. Analytes were dissolved to 1 μM in pH 7.4 phosphate-buffered saline containing 5% dimethyl sulfoxide applied to the donor well and placed on a Teflon acceptor plate prepared with the same solution without analyte. After incubation for ∼16 h, the donor and acceptor plates were separated and quantified via LCMS, via extracted ions.

Assay Information 2

Assay Type -
Permeability Type -
Membrane Measurement Direction (Exclude PAMPA) -
Assay Detail -