Source Name: 2019_Ono
Literature Information
| Literature Title | Conformation and Permeability: Cyclic Hexapeptide Diastereomers |
| Doi | 10.1021/acs.jcim.9b00217 |
| Research Group |
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| Data Number | 8 |
| Minimum Molecular Weight | 712.9 |
| Maximum Molecular Weight | 712.9 |
Assay Information 1
| Assay Type | PAMPA |
| Permeability Type | logPapp |
| Membrane Measurement Direction (Exclude PAMPA) | - |
| Assay Detail | Briefly, a membrane was prepared on a 96-well filter support (donor) with a 1% (w/v) solution of lecithin (soybean) in n-dodecane. Analytes were dissolved to 1 μM in pH 7.4 phosphate-buffered saline containing 5% dimethyl sulfoxide applied to the donor well and placed on a Teflon acceptor plate prepared with the same solution without analyte. After incubation for ∼16 h, the donor and acceptor plates were separated and quantified via LCMS, via extracted ions. |
Assay Information 2
| Assay Type | - |
| Permeability Type | - |
| Membrane Measurement Direction (Exclude PAMPA) | - |
| Assay Detail | - |