Source Name: 2018_CHUGAI
Literature Information
| Literature Title | WO2018225864A1 (Cyclic peptide compound having high membrane permeability, and library containing same) |
| Doi | patents.google.com/patent/WO2018225864A1/en |
| Research Group |
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| Data Number | 374 |
| Minimum Molecular Weight | 1062.3 |
| Maximum Molecular Weight | 1664.2 |
Assay Information 1
| Assay Type | Caco2 |
| Permeability Type | logPapp |
| Membrane Measurement Direction (Exclude PAMPA) | Apical to Basolateral (AB) |
| Assay Detail | Caco-2 cells (CACO-2 Lot No.028; Riken BRC Cell Bank) were seeded onto a 24-well Corning HTS Transwell with pore size 0.4 μm, polycarbonate membrane at a concentration of 1.0*10^5 cells/well. The cells were cultured in DMEM medium containing 10% FBS, penicillin-streptomycin-glutamine, L-glutamine sodium chloride solution and Neaa in an incubator maintained at 37°C and 5% CO2. The medium was changed every 2-3 days and 21-23 days after seeding, we subjected Caco-2 cells to membrane permeability measurements. |
Assay Information 2
| Assay Type | - |
| Permeability Type | - |
| Membrane Measurement Direction (Exclude PAMPA) | - |
| Assay Detail | - |